49ers' George Kittle unlikely to play vs. Seahawks, sources say

San Francisco 49ers tight end George Kittle is unlikely to play in Sunday's game against the Seattle Seahawks, according to multiple sources.

Kittle suffered a calf injury in the 49ers' Week 1 loss to the Chicago Bears and has not practiced this week. The 49ers are hopeful that Kittle will be able to return for their Week 3 game against the Denver Broncos, but they are not ruling out the possibility that he could miss multiple games.

Kittle is one of the most important players on the 49ers' offense. He is a Pro Bowl tight end who has been one of the most productive pass-catchers in the NFL over the past few seasons. In 2021, Kittle caught 71 passes for 910 yards and six touchdowns. He also rushed for 140 yards and a touchdown.

The 49ers are already without wide receiver Deebo Samuel, who is dealing with a hamstring injury. If Kittle is unable to play, the 49ers will be without two of their most important offensive weapons.

The Seahawks are coming off a 17-16 loss to the Denver Broncos in Week 1. They will be looking to bounce back with a win against the 49ers on Sunday.

The 49ers are a 1.5-point favorite in the game, according to DraftKings Sportsbook. The over/under is set at 43.5 points.