Chargers LB Khalil Mack, Bengals OT Orlando Brown Jr. declared inactive for prime-time game

Cincinnati Bengals will be without starting left tackle Orlando Brown Jr. for Thursday night's game against the Los Angeles Chargers.

Brown suffered an ankle injury in last week's loss to the Baltimore Ravens. The Bengals ruled him out for Thursday's game on Wednesday.

With Brown out, Hakeem Adeniji will start at left tackle for the Bengals.

The Los Angeles Chargers will also be without a key defensive player on Thursday night.

Linebacker Khalil Mack has been ruled out with a foot injury.

Mack suffered the injury in the Chargers' Week 1 win over the Las Vegas Raiders. He missed last week's game against the Kansas City Chiefs.

With Mack out, the Chargers will likely start Chris Rumph II at outside linebacker.

The Bengals and Chargers are scheduled to kick off at 8:15 p.m. ET on Thursday night.